Molecular, supramolecular, DNA-binding and biological studies of piperazine and piperidine based dithiocarbamates of biocompatible copper

Abstract

The reaction of dithiocarbamate ligands with CuCl2·2H2O gave the metal complexes of general formula Cu(S2CR)2, where R = N(CH2)4N(Bn) (1), N(CH2)4N(MeO-Ph) (2), N(CH2)4N(C2H4OH) (3), N(CH2)4CHCH(Ph)2 (4) and N(CH2)4CHC(OH)(Ph)2 (5). The characterization was carried out by elemental analysis and spectroscopic methods {FT-IR, UV–Visible, NMR (1H &13C) and single crystal XRD}. The XRD data of three square planar complexes (1–3) revealed that 1 and 3 crystalize in monoclinic space group P21/c and C2/c respectively, while 2 in the triclinic group P-1. A variety of interesting supramolecular motifs have been observed for these complexes ranging from 0- and 1-D chains to 2-D layers and 3-D networks. Moreover, DNA binding capability (determined by UV–Visible spectroscopy, cyclic voltammetry and viscometry) and biological activites (antioxidant, cytotoxicity and antileishmanial) of the synthesized metal complexes were also investigated. The complexes interacted with DNA base-pairs either through the intercalative or by electrostatic mode (complex 2 in CV experiment) with high binding constant values. As for biological activities are concerned, the synthesized compounds were found promising in all the assays.