Abstract
SAGE analysis reveals spatiotemporally regulated transcripts and overlapping sense and antisense transcripts that are important for mouse cerebral cortex development
Highlights
Development of the cerebral cortex requires highly specific spatio-temporal regulation of gene expression
We report validated gene expression profiles that have implications for understanding the associations between differentially expressed transcripts, novel targets and related disorders pertaining to cerebral corticogenesis
The study reports, for the first time, spatiotemporally regulated SRY-box containing gene 4 (Sox4) and SRY-box containing gene 11 (Sox11) antisense transcripts in the brain, neural stem/progenitor cells and P19 cells, suggesting they have an important role in cerebral corticogenesis and neuronal/glial cell differentiation
Summary
Development of the cerebral cortex requires highly specific spatio-temporal regulation of gene expression. The primordial plexiform layer is expanded in the rostro-caudal axis The growth in this axis is always less than the growth in the latero-medial axis. The first wave of migratory neuronal cells form the cortical plate 2 days later after the development of the primordial plexiform layer. These events are followed by the development of the cortical plate into an organization of six distinct layers that forms the adult cerebral cortex. The extensive cyto-architectural and anatomical changes occurring in a spatio-temporal manner during the peak (E15) and at the end (E17) of embryonic cerebral neurogenesis as well as during early postnatal (P1) corticogenesis through to adulthood involves complex underlying molecular regulatory networks
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