Abstract
In inner-ear mechanotransduction, forces from sound and head movement are converted into nerve impulses to facilitate hearing and balance perception. At the apical surface of inner-ear sensory hair cells are actin-filled protrusions called stereocilia. Successively ascending rows of stereocilia form hair-cell bundles that are deflected by force to open transduction channels for cation influx. This causes hair-cell depolarization and initiates sensory perception. Transmembrane channel-like proteins (TMCs) 1 and 2 have been established as the pore-forming components of hair-cell transduction channels.
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