Abstract

肝功能衰竭是由多种因素引起的,以肝细胞大量凋亡、坏死为特征的临床综合征.其病情危重,发展迅速,病死率高达60％～80％.线粒体是真核细胞中一种非常重要的细胞器,与肝脏的生物合成、代谢和解毒功能密不可分.三羧酸循环、脂肪酸β-氧化、氧化磷酸化及鸟氨酸循环等均在线粒体内进行.此外,线粒体在调节细胞内钙离子浓度、信息传递及细胞死亡等过程中也具有重要作用.线粒体是肝细胞内较敏感的细胞器之一,多种急、慢性肝病均存在线粒体结构和功能的异常.有研究结果显示,线粒体与肝衰竭的发病关系密切,可能的作用途径包括:呼吸链被抑制导致三磷酸腺苷(adenosine-triphosphate,ATP)耗竭、氧化应激、脂肪酸β-氧化的抑制、线粒体通透性转换(mitochondrial permeability transition,MPT)所致肝细胞凋亡或坏死等,但其作用机制尚未完全阐明[1].现就目前的相关研究进展作一综述. 关键词：线粒体;肝功能衰竭;氧化应激;细胞凋亡;线粒体通透性转换孔

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.