Molecular mechanisms of inhibition of cellular senescence

Abstract

Introduction. Advances in studying skin ageing processes have proven the importance of high-quality synthesis of type I and III collagen. Protein synthesis is a genetically conditioned process encoded by many genes. Mutations in these genes lead to disorders in this process. The skin ageing genes FLG, AQP3, COL1A1, MMP1, ELN correlate with certain skin morphotypes, and studying the variability of gene transformations opens up new vistas for predicting the development of signs of ageing at any age and, as a result, timely prevention of ageing problems.Aim. To evaluate the effect of skin ageing correction therapy based on the ageing protein expression and the type I and III collagen production according to genetically conditioned ageing variants.Materials and methods. Patients in the comparison groups who had the major signs of skin aging received correction therapy according to regimen 1 (SKINOPRO ACTIVE 8 mg/ml every 7 days) and regimen 2 (SKINOPRO FORTE 12 mg/ml every 7 days). Evaluation of the efficacy of therapy with hyaluronic acid, silica and zinc drugs was based on an analysis of the pathomorphological view of biopsy specimens and an immunohistochemical analysis of Ki-67, p53, AP-1, Collagen I, Collagen III, TGF-b, Klotho, calreticulin expression.Results. The results support the importance of identification of aberrations in genes encoding the skin collagen synthesis to personalize treatment methods for correcting signs of aging in patient with different morphotypes.Conclusion. The article presents interim results of a comparative analysis of methods for correcting involutional changes in the face and neck skin. The possibility of further clinical studies of pharmacological drugs used to correct the morphofunctional signs of aging of the face and neck skin using the presented test findings is discussed.