Abstract
Voltage-gated calcium channels (CaV) control most activity-dependent functions of excitable cells. However, the molecular mechanisms by which different CaV's respond to membrane depolarization with specific gating properties remain unknown. Voltage-dependent gating of CaV channels is determined by four distinct voltage-sensing domains (VSD I-IV) linked to a common channel pore. Each VSD consists of four transmembrane helices (S1-S4) containing four to five positive gating charges. These arginines and lysines interact with negative countercharges in the helices S2 and S3, thus facilitating the outward movement of the S4 helix upon depolarization.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
