Abstract
Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drug with excellent success in the management of human malignancies. Molecular mechanism of action related to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading to DNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to have immunomodulatory properties besides its cytotoxic effect.
Highlights
Platinum AnalogsCisplatin has main antitumor action in numerous solid tumors, cisplatin and the other platinum analogs are extremely cleared via the kidneys through the urine, so, dose adjustment is necessary in the case of renal dysfunction
Platinum analogs includes cisplatin, oxaliplatin and carboplatin
Cisplatin has main antitumor action in numerous solid tumors, cisplatin and the other platinum analogs are extremely cleared via the kidneys through the urine, so, dose adjustment is necessary in the case of renal dysfunction
Summary
Cisplatin has main antitumor action in numerous solid tumors, cisplatin and the other platinum analogs are extremely cleared via the kidneys through the urine, so, dose adjustment is necessary in the case of renal dysfunction. Platinum analogs have the same clinical pharmacological action, cytotoxic effect and mechanisms of resistance as cisplatin [1]
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