Abstract
This research investigates the molecular interaction between vitamin C (ascorbic acid) and glutathione peroxidase (GPX), a key enzyme in the antioxidant defense system. Oxidative stress-induced damage, caused by an imbalance in reactive oxygen species (ROS) production, is implicated in various health issues. Vitamin C, a potent antioxidant, is known for its ability to neutralize free radicals and support overall cellular health. Despite numerous studies on the protective effects of vitamin C, the molecular details of its interaction with GPX remain unclear. In this study, we employ computational methods, including molecular docking and dynamics simulations, to predict and visualize the molecular-level interaction between vitamin C and GPX. Our results reveal a favorable binding affinity, supported by negative free energy values, suggesting strong interactions. Detailed analyses of various parameters provide insights into the structural flexibility of the ligand, vibrational dynamics, and clustering characteristics. Overall, this study enhances our understanding of the molecular mechanisms underlying the beneficial effects of vitamin C in combating oxidative stress, with potential implications for therapeutic interventions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Medicinal and Analytical Chemistry International Journal
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
