Molecular genetic aspects of individual differences in pain sensitivity and thermoregulation

Abstract

The molecular genetic aspects of individual differences in thermoregulation and pain sensitivity that may be used to evaluate and predict the physical state of humans under contrast climate conditions, as well as during high physical and psychic loads, are reviewed. In response to abrupt changes in both external and internal temperature, the body activates internal resources that support homeostasis and adapts to the environment. Active movements are often associated with traumas accompanied by a sense of pain whose intensity and suppression depend on individual body characteristics. Understanding the functioning of the systems of thermoregulation and pain sensitivity at the molecular level and study of the polymorphism of genes involved in these processes is important for creation of optimal conditions for both rapid adaptation to the loads of everyday life and high physical activity and for success in sports.