Abstract
Background. Increase in incidence rates of enterovirus infections in the Far Eastern Federal District of Russia is observed annually. There is a wide genetic diversity of circulating non-polio enteroviruses. Some of them have been constantly identified for a number of years in the population of the district, including the Coxsackie A10 virus.Purpose. To study the features of the Coxsackievirus A10 circulation in the Far Eastern Federal District of Russia in 2014–2018.Methods. For this work, 117 Coxsackievirus A10 complete sequences of the VP1 gene were used, which were isolated in the Far Eastern Federal District of Russia in 2014–2018.Results. Phylogenetic analysis revealed two Coxsackievirus A10 lineages in the Far Eastern Federal District of Russia in 2014-2018, while their simultaneous circulation was noted in the Sakhalin region in 2017. Active population migration contributes to the widespread distribution of Coxsackievirus A10 in border areas with the formation of epidemic variants.Conclusion. Coxsackievirus A10 is one of the most relevant types of non-polio enteroviruses for the Far Eastern Federal District of Russia. Phylogenetic analysis revealed its genetic diversity and suggested both European and Asian origin of the obtained strains.
Highlights
Increase in incidence rates of enterovirus infections in the Far Eastern Federal District of Russia is observed annually
117 Coxsackievirus A10 complete sequences of the VP1 gene were used, which were isolated in the Far Eastern Federal District of Russia in 2014–2018
Phylogenetic analysis revealed two Coxsackievirus A10 lineages in the Far Eastern Federal District of Russia in 2014-2018, while their simultaneous circulation was noted in the Sakhalin region in 2017
Summary
ФБУН «Хабаровский научно-исследовательский институт эпидемиологии и микробиологии» Роспотребнадзора, 680610, Хабаровск, Россия. При этом отмечается широкое разнообразие циркулирующих неполиомиелитных энтеровирусов. Изучить особенности циркуляции энтеровируса Коксаки А10 на территории ДФО в 2014–2018 гг. Для работы были использованы 117 полных нуклеотидных последовательностей гена VP1 энтеровируса Коксаки А10, которые были выделены в ДФО в 2014–2018 гг. По результатам филогенетического анализа выявлены две генетические линии Коксаки А10, при этом в Сахалинской области в 2017 г. Энтеровирус Коксаки А10 является одним из наиболее актуальных типов неполиомиелитных энтеровирусов для ДФО. Авторы заявляют об отсутствии финансирования при проведении исследования. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи. Для цитирования: Бутакова Л.В., Сапега Е.Ю., Троценко О.Е. Молекулярно-эпидемиологические особенности циркуляции энтеровируса Коксаки А10 в Дальневосточном федеральном округе.
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