Enterovirus types and clinical characteristics of 5 070 cases with hand, foot and mouth disease in Shen-yang area, 2014

Abstract

Objective To study the epidemic characteristics, distribution of pathogen and clinical characteristics of hand, foot and mouth disease in Shenyang area, 2014. Methods Swab specimens was collected from 5 070 cases of hand, foot and mouth disease caces, the F- PCR method was adopted for enterovirus 71(EV71), coxsackievirus A 16(CA16) and universal enteroviruses(EU) detection, and combining the relevant clinical data for comparative analysis . Results June to August was the peak epidemic period.5 070 nasopharyngeal swab specimens were detected positive 3 715 intestinal virus nucleic acid, and the detection rate was 73.27%, including CA16 positive 1 481(39.87%), EU positive 1 148(30.90%), EV71 positive 1 086(29.23%). The proportion of EU positive was highest in June(29.71%). The proportion of EV71 positive(24.78%) and CA16 positive(33.27%) were highest in July, respectively .The proportion of nervous system symptoms in EV71 infection group(88/112, 78.57%)was higher than those in EU infection group(97/147, 65.99%)and CA16 infection group(44/78, 56.41%). The proportion of abnormal myocardial enyzme in CA16 infection group(37/78, 47.44%) was higher than those in EU infection group(48/147, 32.65%)and EV71 infection group(34/112, 30.36%) . Conclusion CA16 is the major pathogen causing hand, foot and mouth disease in Shenyang area, 2014.Severe hand, foot and mouth is still dominated by EV71. Key words: Hand, food and mouse disease; Enterovirus 71; Coxsackievirus A 16; Universal Enteroviruses