Abstract
The structural preferences of curcumin (C21H20O6) molecule were analyzed by
 MMFF method using Spartan06 program and the most stable geometry was
 determined. To evaluate the effects of curcumin on SARS-CoV-2, the molecular
 docking studies have been done on the spike glycoprotein and the apo/holo forms of
 the SARS-CoV-2 major protease enzyme (Mpro). The binding affinities and binding
 modes of curcumin targeted to the SARS-CoV-2 proteins were determined. It was
 discovered that curcumin had binding affinities of -7.3, -5.7, and -7.6 kcal/mol to the
 apo and holo forms of the major protease enzyme (Mpro) and spike glycoprotein,
 respectively. The findings suggested that curcumin could be a useful therapeutic
 agent for COVID-19 treatment.
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