Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt.

Vadivel Mani

doi:10.6026/97320630017916

Abstract

Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment. Hence, novel problem-solving approaches for assessing early metabolic diseases, notably insulin resistance, are urgently needed. Screening of natural compounds for drug discovery to combat diabetes is common in modern medical research and development. Therefore, it is of interest to document the molecular docking analysis data of beta-Caryophyllene, a naturally occurring sequiterpene with the downstream insulin signaling molecules such as IRS-1, cSrc and Akt for the management of type-2 diabetes. The molecular docking analysis data of beta-caryophyllene with the insulin downstream signaling molecules such as IRS-1, cSrc and Akt reveals its ability and further studies are needed to elucidate its complete mechanism of action against type-2 diabetes.

Highlights

Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment
Diabetes mellitus (DM) is a common metabolic illness defined by processes [2]
Insulin attaches to insulin receptor (IR) located on the hyperglycemia caused by insufficient production or absent of surface of cell membranes, which causes the receptor to pancreatic insulin, with or without concomitant insulin action autophosphorylate

Summary

Research Article

Declaration on official E-mail: The corresponding author declares that official e-mail from their institution is not available for all authors. Declaration on Publication Ethics: The author’s state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors declare that they are not withholding any information that is misleading to the publisher in regard to this article

Results and Discussion

ID Docking score Amino acids involved in interaction

References: