Abstract
Trypanosomatids are uniflagellate protozoa belonging to the Trypanosomatidae family. The genera Trypanosoma and Leishmania are of paramount importance as they contain species that cause serious diseases, such as Chagas disease and Leishmaniasis, respectively. The objective of the present study was to identify trypanosomatids present in the whole blood of free-living and captive neotropical primates in Mato Grosso State, Midwest Brazil. Between 2017 and 2019, 38 blood samples were collected from seven different neotropical primate species in seven cities in the state. Through molecular techniques, including polymerase chain reaction (PCR) to amplify a fragment of the kinetoplast DNA (kDNA) and 18S ribosomal RNA (18S rRNA) gene, sequencing, and phylogenetic analysis, nine Leishmania spp. [seven L. infantum and two L. (Leishmania) amazonensis] and two Trypanosoma spp. (T. minasense and T. rangeli) were identified. This study contributes to understanding the occurrence and epidemiology of trypanosomatids in Mato Grosso State and the importance of neotropical primates as trypanosome hosts and possible infection sources for other animals and humans. Future identification of other blood pathogens in neotropical primates will assist in disease control and prevention strategies.
Highlights
Trypanosoma and Leishmania are uniflagellate protozoa belonging to the Trypanosomatidae family (Ortiz & Solari, 2019)
Some species are pathogenic to animals and humans, such as Trypanosoma cruzi and Leishmania infantum, which are responsible for Chagas disease and Visceral Leishmaniasis, respectively (Kaufer et al, 2017)
Wild animals are susceptible to infection, and as a group, neotropical primates are of great significance as they can act as reservoirs for these pathogens (Solórzano-García & Pérez-Ponce de León, 2018)
Summary
Molecular detection of trypanosomatids in neotropical primates in the state of Mato Grosso, Midwest, Brazil. Detecção molecular de tripanossomatídeos em primatas neotropicais no estado de Mato Grosso, Centro-Oeste, Brasil. Stéfhano Luís Cândido; Lucas Avelino Dandolini Pavelegini; Thábata dos Anjos Pacheco; Richard de Campos Pacheco3* ; Victória Luiza de Barros Silva; Thais Oliveira Morgado; Edson Moleta Colodel; Luciano Nakazato; Arleana do Bom Parto Ferreira de Almeida; Valéria Dutra. How to cite: Cândido SL, Pavelegini LAD, Pacheco TA, Pacheco RC, Silva VLB, Morgado TO, et al Molecular detection of trypanosomatids in neotropical primates in the state of Mato Grosso, Midwest, Brazil. Braz J Vet Parasitol 2021; 30(2): e001321.
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