Abstract
Growth differentiation factor 5 ( GDF5 ), involved in the development and maintenance of bone andcartilage, is a n important candidate gene for growth and carcass traits selection through markerassisted selection (MAS). Genomic structural analysis showed that bovine GDF5 shares much similarity with human GDF5 . The latest findings demonstrate that the single nucleotide polymorphism (SNP) T586C in exon 1 is significantly associated with ultrasound marbling score (UMAR) and ultrasound backfat thickness (UBF). Furthermore, the analysis of T586C SNP marker shows there are significant effects on the UBF (P = 0.0498) and on the UMAR (P = 0.0058) in 465 individuals. These results clearly suggest that the GDF5 gene is among target genes for carcass traits in bovine reproduction and breeding. Keywords: Cattle, GDF5 gene, ultrasound measurement, polymorphism, association analysis African Journal of Biotechnology Vol. 9(33), pp. 5269-5273, 16 August, 2010
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