Abstract
Comparable neuroprotective effect of rapamycin against low and high rotenone concentrations in primary dopaminergic cell cultureKhaled Radad, Rudolf Moldzio, Mubarak Al-Shraim, Ahmed Al-Emam, Wolf-Dieter Rausch
Highlights
Stem cells (SCs) are defined as cells having the ability to self-renew, and to differentiate into multiple phenotypic lineages (Tuszynski et al, 1996)
This study aimed to demonstrate the fate of human olfactory bulb neural stem cells
glial fibrillary acidic protein (GFAP)-expressing astrocytes constituted the highest population of cells followed by CSPGS-expressing immature oligodendrocytes, Microtubule-associated protein 2 (MAP2)-expressing immature neurons, and forkhead box protein O4 (FOXO4)-expressing mature oligodendrocytes
Summary
Stem cells (SCs) are defined as cells having the ability to self-renew, and to differentiate into multiple phenotypic lineages (Tuszynski et al, 1996). Thereby, human adult olfactory bulb NSCs (hOBNSCs) provide an attractive tool for transplantation-based therapy of neurodegenerative diseases that avoids the ethical and moral questions associated with the use of human embryonic or heterologous material (Casalbore et al, 2009; Marei et al, 2016). None of the markers are completely exclusive for NSC, some of them including nestin, NR4A1, SOX2, and MSI1, are highly enriched in SC populations (Nakano et al, 2005). Nestin is down-regulated and substituted by other intermediate filament proteins such as glial fibrillary acidic protein (GFAP) in astrocytes or neurofilaments in neuronal cells (Michalczyk and Ziman, 2005). SOX2 is a transcription factor essential for maintaining self-renewal of undifferentiated embryonic SCs (Pevny and Nicolis, 2010).
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