Abstract
Measles is a human infectious disease of global concern that is caused by the measles virus. In this study, we report the complete genome sequencing of one measles virus isolate, genotype D8, that was obtained directly from a urine sample in Boa Vista city, the capital of Roraima state in Brazil. Phylogenetic reconstruction grouped the genome described in this study with that of samples from Australia, South Korea, and Italy. To our knowledge, this is the first complete genome sequence of a wild-type measles virus reported from Latin America. Therefore, the present data strengthen the current knowledge on the molecular epidemiology of measles worldwide.
Highlights
Measles is a highly contagious airborne disease that begins as an acute febrile illness characterised by symptoms such as fever, coryza, conjunctival hyperaemia, cough, and a maculopapular skin rash
Since the 1980s, the total number of deaths related to measles dropped from more than 2 million per year to approximately 100,000 per year due to the improvement of social indicators and global efforts to increase vaccination coverage.[1] timely surveillance of suspected measles cases with highly sensitive and specific molecular diagnostic tools combined with genetic characterisation of the isolates is of paramount importance for the global efforts to eliminate the virus.[1,3]
In August 2018, the Central Laboratory of Roraima state (LACEN-RR) started testing samples from suspected measles cases using the real-time polymerase chain reaction (PCR) protocol developed by the Centers for Disease Control and Prevention (CDC), USA
Summary
Measles is a highly contagious airborne disease that begins as an acute febrile illness characterised by symptoms such as fever, coryza, conjunctival hyperaemia, cough, and a maculopapular skin rash. We subsequently conducted a maximum likelihood phylogenetic analysis with PhyML software[8] using the N gene region of the Roraima sample, the genotypes reference sequences available in the Measles Nucleotide Surveillance (MeaNS) database (http://www.whomeasles.org/), and four other sequences representing the genotype D8 lineages
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