Abstract
An fluorescence quenching effect due to few-walled carbon nanotubes chemically modified by carboxyl groups has been utilized to discriminate Single Nucleotide Polymorphism (SNP). It was shown that the complex obtained from these nanotube and singlestranded primer DNA is formed due to stacking interactions between the hexagons of the nanotubes and aromatic rings of nucleotide bases as well as due to establishing of hydrogen bonds between acceptor amine groups of nucleotide bases and donor carboxyl groups of the nanotubes. It has been demonstrated that these complexes may be used to make highly effective DNA biosensors detecting SNPs which operate as molecular beacons.
Highlights
Single Nucleotide Polymorphism (SNP) is the most prevailing mutation of genome
We show in this paper that the complex Single stranded deoxyribonucleic acid (ssDNA)/few-walled CNTs (FWCNTs) is formed due to stacking interactions between the hexagons of carbon nanotubes (CNTs) and aromatic rings of nucleotide bases as well as due to establishing of hydrogen bonds between acceptor amine groups NH of nucleotide bases and donor carboxyl groups of the nanotubes
transmission electron microscopy (TEM) images of complexes FWCNT/ssDNA in figures 1b and 2 demonstrate that FWCNTs were covered by electrondense layers of self-assembled oligonucleotide
Summary
- Specificity Bio-identification of CNT-Based Transistor Sheng-Yu Wang and Hue-Min Wu. - Variant discovery in the sheepmeat odour and flavour in javanese fat tailed sheep using RNA sequencing M A M Abuzahra, Jakaria, K Listyarini et al. - Marker traits association of agronomical traits correlated with stagnant flooding tolerance in rice T Sitaresmi, D W Utami, W B Suwarno et al. V P Egorova, H V Krylova, I V Lipnevich, A A Veligura, B G Shulitsky, L.Y. Fedotenkova
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