Abstract
Abstract Behcet's disease (BD) is an autoinflammatory disease caused by several genetic, epigenetic, immunologic, and environmental factors. This study aimed to evaluate the association between CTLA4 gene +49A/G polymorphism and risk as well as clinical manifestations of BD in the Iranian Northwest Azeri population. In this study, 47 BD patients and 61 healthy controls were enrolled. CTLA4 gene +49A/G genotyping was conducted via the tetra-primer amplification refractory mutation system–polymerase chain reaction (T-ARMS–PCR). CTLA-4 gene expression was determined by Real-time PCR and the serum level of CTLA-4 protein (sCTLA-4) was evaluated by ELISA. The A allele (OR = 3.133, 95%CI = 1.53–5.59, P = 0.005) and AA genotype (OR = 5.54, 95% CI = 2.48–13.10, P
Published Version
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