Abstract
ABSTRACT Methanol and ethyl acetate fractions (MF and EF, respectively) of Alstonia boonei stem bark were investigated for their mitochondrial-mediated apoptosis in rat liver mitochondria. With Ca2+, EF potentiated the Ca2+-induced mitochondrial membrane permeability transition (MMPT) pore opening with induction fold of 2, 3, 4, and 5 at 10, 20, 40, and 80 µg mL−1, respectively, while the MF reversed Ca2+-induced MMPT pore at the same concentrations. Both MF and EF inhibited the lipid peroxidation. The EF enhanced mitochondrial ATPase activity, cytochrome c release, and caspase 3 and 9 activities. Terpenes were the most abundant natural products in EF. EF has bioactive agents that can modulate mitochondrial-mediated apoptosis.
Published Version
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