Modulation of responses and frequency tuning of thalamic and collicular neurons by cortical activation in mustached bats.

Abstract

In the Jamaican mustached bat, Pteronotus parnellii parnellii, one of the subdivisions of the primary auditory cortex is disproportionately large and over-represents sound at approximately 61 kHz. This area, called the Doppler-shifted constant frequency (DSCF) processing area, consists of neurons extremely sharply tuned to a sound at approximately 61 kHz. We found that a focal activation of the DSCF area evokes highly specific corticofugal modulation in the inferior colliculus and medial geniculate body. Namely a focal activation of cortical DSCF neurons tuned to, say, 61. 2 kHz with 0.2-ms-long, 100-nA electric pulses drastically increases the excitatory responses of thalamic and collicular neurons tuned to 61.2 kHz without shifting their best frequencies (BFs). However, it decreases the excitatory responses of subcortical neurons tuned to frequencies slightly higher or lower than 61.2 kHz and shifts their BFs away from 61.2 kHz. The BF shifts are symmetrical and centrifugal around 61.2 kHz. These corticofugal effects are larger on thalamic neurons than on collicular neurons. The cortical electrical stimulation sharpens the frequency-tuning curves of subcortical neurons. These corticofugal effects named "egocentric selection" last </=2.5 h after the cessation of a 7-min-long cortical electrical stimulation. In the mustached bat, corticofugal modulation serves to increase the contrast in neural representation of sound at approximately 61 kHz, which is an important component of an echo bearing velocity information. It is also most likely that the corticofugal system plays an important role in plasticity of the central auditory system. Another subdivision of the auditory cortex of the mustached bat is called the FM-FM area. This area consists of delay-tuned combination-sensitive neurons, called FM-FM neurons, and has the echo-delay axis for the systematic representation of target distances. A focal electric stimulation of the FM-FM area evokes changes in the responses of collicular and thalamic FM-FM neurons. These changes are basically the same as those described in the present paper. Therefore corticofugal modulation takes place for frequency domain analysis in exactly the same way as it does in time domain analysis.