Modulation of Renal Aquaporin-3 by Swimming Exercise in Fructose Induced Metabolic Syndrome

Abstract

AbstractBackground: Metabolic syndrome is cluster of cardiovas-cular and metabolic pathologies, caused by high fructose in modern times.Aim of Study: We investigated the possible beneficial role of exercise on fructose induced metabolic syndrome in rats with special focus on the role of renal aquaporin-3 (AQP3).Material and Methods: Forty rats were divided into four groups; control, exercised control, MetS (Metabolic Syn-drome), and MetS with exercise. MetS was induced by fructose rich diet and swimming was practiced 3 days per week for 6 weeks, one hour each session.Results: Fructose consumption significantly increased fact accretion, systolic blood pressure, serum lipids, insulin levels and insulin resistance. Also serum MDA, uric acid and renal AQP3 expression increased compared to the control group. Swimming exercise significantly decreased the previ-ously measured parameters compared to fructose group but overexpressed renal AQP3.Conclusion: Increased AQP3 expression may be implicated in fructose induced MetS. Swimming exercise efficiently counteracted metabolic disruption and vascular affection via lowering effect on oxidant and dyslipidemic stresses with renal aquaglyceroporin-3 overexpression.