Modulation of P2Y12 Receptor Prevents Cognitive Decline and Oxidative Stress Induced by Chronic Cerebral Ischemia

Abstract

Stroke is a chronic disabling condition characterized by loss of motor skills and cognitive abilities. The unpredictability of stroke is one of the biggest challenges for its prevention. The time period after ischemic episode is so narrow that majority of the strokes end up in disabilities for life. Stroke - irrespective of hemorrhagic or ischemic origin leads to activation of platelet aggregation cascade and triggers the neuro and vascular inflammatory cascades. In stroke patients the levels of oxidative stress are measured very high and this increased ROS burden may be the reason behind the neuronal death. So, we have observed the role of P2Y12 receptors in reducing platelet aggregation and neuro-inflammatory pathways. The blockage of the P2Y12 receptors also leads to the reduced platelet aggregation and may lead to less instance of clot development and reduce the post stroke morbidities. Hence, we are hypothesizing that modulation of P2Y12 receptors may prove beneficial for the stroke subjects.