Abstract

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Highlights

  • Protection of fish against bacterial diseases by specific vaccines has been an important method for many years in aquaculture

  • When a fish initially encounters a pathogen, the nonspecific defence mechanisms are more important than the specific immune response, as the latter requires a long time for antibody build-up and specific cellular activation

  • Iysosomes fuse with the phagosome forming a phagolysosome and the infectious agent is killed by a battery of microbicidal mechanisms

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Summary

Introduction

Protection of fish against bacterial diseases by specific vaccines has been an important method for many years in aquaculture. Several promising synthetic drugs and biological response modifiers stimulate or modulate the nonspecific defence mechanisms and specific cellular and humoral immune responses in fish.

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Conclusion
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