Abstract
Cardiac remodeling is the pathological ramification of myocardium resulting into various cardiac diseases. Oxidative stress represents a self-perpetuating mechanism by producing excess reactive oxygen species (ROS) and plays a critical role in cardiac remodeling. A redox state that maintains the homeostatic balance in the cell is critical in cardiac remodeling. A misbalance of redox state triggers cellular damage and promoting adverse signaling pathways leading to apoptosis. MicroRNAs (miRNAs) are short, 19–21 nucleotides, endogenous noncoding RNAs modulate gene regulation, elicits a vital role in cardiac remodeling including cardiac hypertrophy, fibrosis, myocardial injury and arrythmia via multiple mechanisms. Recent studies indicated that miRNAs are influencing the generation of ROS and modulate antioxidant defense mechanism by regulating antioxidative enzymes and are termed as “redoximiRs.” Here, I review the current progress and the mechanisms by which “redoximiRs” regulate cardiac remodeling.
Published Version
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