Abstract
The aim of this project is to assess the anti-bacterial and anti-inflammation properties of a matrix-type silicone elastomer device providing sustained release of DL-lactide (a cyclic ester dimer of lactic acid). Lactide-loaded matrices were prepared by injection molding, and the devices were assessed for of in vitro release, anti-bacterial activity, and anti-inflammatory activity. The devices provided sustained release of lactide/lactic acid over five days and were effective against E. coli and S. aureus. Further, the devices reduced inflammation through activation of the GPR81 receptor via the NF-κB and JAK-STAT signalling pathway. These lactide-releasing silicone elastomer devices could improve clinical outcomes with certain short-term medical devices.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
