Abstract
The interactions among effects of thyroid status, glucagon, and dibutyryl cAMP (DBcAMP) on the regulation of hepatic metabolism of FFA were studied in perfused livers isolated from euthyroid, hypothyroid, and hyperthyroid male rats. The animals were made hypothyroid by treatment with propylthiouracil or hyperthyroid by treatment with T3. Uptake of oleic acid by perfused livers was not altered by treatment of the animal with T3 or propylthiouracil, or by addition to the medium of glucagon (10-9 M), DBCAMP (2 × 10-5 M), or methylisobutylxanthine (MIX; 2 HIM). In agreement with previous data, hepatic formation and secretion of triglyceride were diminished and ketogenesis was stimulated by hyperthyroidism, glucagon, and DBcAMP. These effects of diminished triglyceride output and enhanced ketogenesis observed in hyperthyroidism were exacerbated by glucagon, while livers from hypothyroid rats were insensitive to the effects of glucagon. MIX, a phosphodiesterase inhibitor, reversed the insensitivity of the liver...
Published Version
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