Abstract
The modulation by dopamine of the binding of [ 3H]BTCP to the dopamine (DA) uptake complex was investigated in vivo (in control, reserpine- and l-DOPA-treated mice) and in vitro (on membrane preparations of the striatum of the rat). In both cases increasing doses of DA exerted a non-competitive inhibition of binding of [ 3H]BTCP, with a K i value close to its K 0.5, determined in competition experiments. Amphetamine and cocaine were also non-competitive inhibitors of the binding of [ 3H]BTCP, while GBR 12783 was competitive. In the presence of DA, the amount of cocaine required to inhibit the binding of [ 3H]BTCP was increased both in vitro and in vivo. These results suggest that inhibitors of the uptake of DA, such as BTCP or GBR 12783, modulate allosterically the uptake of DA, by binding to a site different from the DA recognition site. Cocaine, however, seems to share the same recognition site as DA.
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