Abstract
The effect of dopamine (DA) on [3H]N-[1-(benzo(b)thiophenyl)cyclohexyl] piperidine ([3H]BTCP, a phencyclidine derivative) binding to the dopamine uptake complex has been investigated in vitro (rat striatal membranes) and in vivo (mouse brain). In both binding assays DA was found to behave as a non competitive inhibitor of [3H]BTCP binding. These results suggest the presence of a DA uptake modulatory site distinct from the DA recognition site on the carrier.
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