Modulation by Casein and Soybean Protein Amino Acid Mixtures of Insulin- and Glucagon-dependent Linoleic Acid Desaturation in Primary-cultured Rat Hepatocytes

Abstract

The effects of amino acid mixtures simulating to casein and soybean protein on insulin- and glucagon-dependent linoleic acid desaturation were studied in rat hepatocytes of up to 72 h of culture. The desaturation increased with the insulin molarity in the medium, but decreased with the glucagon molarity. The soybean protein type of amino acid mixture, compared to the casein type of amino acid mixture, potentiated the insulin-dependent desaturation. Thus, dietary proteins could moidify in vivo insulin-dependent intracellular metabolism through postprandial amino acids in blood plasma.