Abstract
The 3-component lipid mixture DSPC/POPC/CHOL exhibits a rich equilibrium compositional phase diagram. When a fourth lipid component, DOPC, is titrated in to replace POPC, unusual phase separation emerges in a portion of the composition space. Elongated stripe and honey comb like structures of coexisting liquid ordered and liquid disordered phases are observed in giant unilamellar vesicles. GUV images were examined by fluorescence wide field, 2-photon, and confocal microscopies. The specific mechanisms by which this phase modulation is driven are not yet well understood. The work of Seul and Andelman suggests that the formation of these structures may be driven by multiple order parameters with competing interactions. We analyzed many different order parameters and interactions using the formalism of field theory, diffusion kinetics, and computational modeling to better characterize the microscopic details of this novel phase behavior.
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