Modified millet extract-mediated NiO/CaO Nanocomposite potentiometric sensor for monitoring of ciprofloxacin in commercial products

Abstract

The super useful capability of nickel oxide (NiO) and calcium oxide (CaO) nanoparticles (NPs) has inspired critical interest in the usage of these nanomaterials as a wonderful and potentially active nanocomposite in ion selecting and detecting studies. This study created a NiO/CaO nanocomposite (NiO/CaO NCS) functionalized wire sensor to quantify ciprofloxacin (CPX) in medicines. Ciprofloxacin was coupled with phosphomolybdic acid (PMA) to give ciprofloxacin phosphomolybdate (CPX-PM) as an electrically active compound in the existence of polyvinyl chloride and the fluidizing medium o-nitrophenyl octyl ether (o-NPOE). The developed sensor exhibits exceptional sensitivity and selectivity for the measurement and estimation of CPX, with linearity ranging from 1.0 × 10−10 to 1.0 × 10−2 mol L−1. EmV = −57.25 ± 0.5 (log [CPX]) + 832.61 was estimated as the regression equation. In contrast, the standard type CPX-PM showed a potential response in a concentration range of 1.0 × 10−6 to 1.0 × 10−2 mol L−1 and a regression equation of EmV = −54.745 ± 0.7 (log [CPX]) + 469.34. The functionalized sensor was potentially utilized for the quantification of CPX in its commercial Tablets.