Abstract
We presented a new approach to produce Chitosan–Glutaraldehyde–Chitosan–Alginate (CGCA) hollow fiber with the capability of cell capture and adhesion for vascular tissue engineering. The CGCA hollow fiber was generated by sacrificing the inner part of alginate/chitosan (A/C) solid fiber using sodium citrate, followed by glutaraldehyde (GA) cross-linking chitosan to form stable imine bonds on the fiber surface. Furthermore, human umbilical vein endothelial cells (HUVEC) were captured by the CGCA hollow fiber surface and adhesive as layer pattern with good viability and normal morphology. This strategy facilitated the lumen structure formation with good biocompatibility by biomaterials modification, providing a promising and facile technique for blood vessel regeneration in vitro and in vivo.
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