Abstract
The effect of p-chlorophenylalanine (p-CPA) on testosterone (T) hypothalamic metabolism and on plasma levels of T, estradiol (E 2) and corticosterone (B) was studied in male rats and rabbits: both were sacrificed 48 hours after the last injection. In both rats and rabbits a significant increase in T→E 2 transformation (aromatization) was evident after p-CPA treatment. This increase could be responsible for the stimulatory effect on sexual behavior which has been described in literature following p-CPA administration. Moreover p-CPA caused a decrease of circulating T and E 2 in both species.
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