Modification of x-ray survival curves of stem-cells by different doses of erythropoietin.

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A PREVIOUS study of stem-cell response to erythropoietin in the polycythaemic mouse after 150 rads showed an initial depression to values between 5 and 15 per cent of unirradiated controls1. Gurney2, however, in an earlier publication, reported an erythropoietin response after a single dose of 150 rads of about 30–40 per cent of control. The experiments were similar except for the dose of erythropoietin used: in our experiments about 0.5 unit (M.R.C. Standard ‘A’)3 and in Gurney's 6 units Armour Company erythropoietin (≍ 10 units M.R.C. Standard ‘A’). We therefore decided to investigate whether or not the dose of erythropoietin influences the apparent radiation effect in this system.