Modification of the Crystallographic Structure of Olanzapine during Solvation by PALS and X-Ray Diffraction Methods

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Two selected solvents were incorporated into the olanzapine structure. Molecules located inside the voids in the structure caused the changing of the o-Ps lifetime and intensity. After removing the n-butanol●H2O molecules, the materials returned to its initial structure. Creating the complex with the methanol●H2O leads to the change of the crystallographic structure of the olanzapine.