Abstract
Although viral vector systems are efficient to transfect foreign genes into a variety of tissues, safety issues remain in relation to human gene therapy. In this study, we examined the feasibility of a novel nonviral vector system by using high-frequency, low-intensity ultrasound irradiation for transfection into vascular cells, kidneys and the central nerve systems of fetal mice. As a result, expression of the reporter gene, Venus, was readily detected in the central nervous system. The transfected cells were mainly detected in meningeal cells with intracisternal injection. Overall, the present study demonstrated the feasibility of efficient plasmid DNA transfer into several organs, especially the central nervous system, providing a new option for treating various diseases.
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