MODIFICATION OF NEURAL INTERACTIONS AND FUNCTIONAL ACTIVITY OF MEDIATOR SYSTEMS UNDER CONDITIONS OF METABOLIC SYNDROME

Abstract

The review examines the peculiarities of mediator systems under the conditions of metabolic syndrome. The processes of oxidative stress that occur in adipose tissue are described and can be caused not only by an increase in ROS production, but also by a decrease in the antioxidant protection of adipocytes. Features of the eff ects of antioxidant enzymes are shown, which creates prerequisites for further study of their activity in various tissues against the background of metabolic disorders characteristic of metabolic syndrome. Convincing evidence is provided that functional changes in the expression, activity, and regulatory properties of neuronal NO synthase play a key role among the molecular causes of MS. Understanding the molecular basis of the functioning of the signifi cant components of the NO cycle, the patterns of their changes, the relationship between this cycle and oxidative and nitrosative stress will allow in the future to develop methods of more eff ective diagnosis, treatment and prevention of metabolic syndrome.