Abstract
This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca. 35% in 90 min in acidic media.
Highlights
Silica nanoparticles are prepared with different surface area, size, shape, and surface functionality
Transmission electron microscopy (TEM) image reveals that prepared samples are dispersed without aggregation, with a diameter ranging from 150 to 250 nm, which shows a good agreement with the Scanning electron microscopy (SEM) image (Figure 1(b))
No significant differences in SEM and TEM images were observed between nonmodified and modified mesoporous silica nanoparticles (MSNs), which is similar to the observation reported previously [42]
Summary
Silica nanoparticles are prepared with different surface area, size, shape, and surface functionality. Huang et al have prepared a catalyst based on modified mesoporous silica coated with MPTMS. Cheng et al reported the functionalization of MSNs with pH-sensitive trimethylammonium as pH-controllable drug release [24]. Xia et al reported the preparation of MSNs coated with amine and encapsulated doxorubicin inside their pores and sealed the external surface with cellulose through esterification [25]. Liu and coworkers reported the synthesis of MSNs coated with amine and used to load with doxorubicin (Dox) [26]. Chen et al reported the preparation of mesoporous silica modified with amine for loading and releasing Dox using a capping concept. E drug can be released with control minor by detachment of the capped nanoparticles that block the MSN pores [27] Chen et al reported the preparation of mesoporous silica modified with amine for loading and releasing Dox using a capping concept. e drug can be released with control minor by detachment of the capped nanoparticles that block the MSN pores [27]
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