Abstract
Uterine vascular clamping of the pregnant rat uterus for 45 minutes protects against the lethal and growth-retarding effects of irradiation on the eighth day of gestation and against the lethal, growth-retarding, and probably teratogenic effects of irradiation on the ninth day of gestation. If the clamping procedure is continued for more than an hour on the eighth and ninth days; it results in a high incidence of malformations. The most likely basis for the protective effect of the clamping procedure is the resultant hypoxia, but the definitive answer is not yet available. The inability of irradiation to induce malformations in the 8-day 0-hour-old rat embryo was confirmed. The discrepancy between the teratogenic action of vascular clamping and irradiation on the eighth day is presented and discussed. (auth)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call