Modification of bioadhesive based on crosslinked alginate and gelatin

Abstract

The increasing need for adhesive products in various fields has prompted several studies to seek alternatives for synthetic adhesives. A novel tissue adhesive based on two biocompatible and biodegradable polymers (alginate and gelatin) combined with citric acid and p-toluenesulfonic acid (pTSA) was developed by our research group. This study aims to improve the mechanical properties of bioadhesives based on alginate and gelatin. The process of bioadhesive synthesis was started with alginate modification by crosslinking method using calcium sulfate (CaSO4·2H2O). The synthetic process was carried out at 80 °C for 30 min. Furthermore, the crosslinked alginate was then mixed with gelatin, citric acid, and pTSA catalyst and allowed to react at 80 °C for 60 min. The experiment was repeated for various mass ratio crosslinked alginate (AG-CL):gelatin compositions. The adhesion property of products was evaluated by tensile strength test and viscosity measurement. The result of the tensile strength test showed that there was an effect of adding crosslinked alginate to the adhesive strength. There was a composition that has maximum viscosity and maximum tensile strength. The composition was AG-CL:gelatin (2:1). Based on the obtained product, it will be known whether the adhesive is the potential to be used as tissue adhesive and developed in the future.