Abstract
The morphological and the primary transcript levels of the genes for aquaporin AaAQP4 and the membrane transporter AaV-H+-ATPase in the anal papillae of A. aegypti larvae exposed to squamocin were evaluated. Squamocin caused great vacuolization in the anal papillae wall, basal lamina disruption with loss of canalicular spaces, and disorganization of the cuticular layers. There was also decrease of AaAQP4 transcript levels and inhibition of AaV-H+-ATPase in the anal papillae of larvae. Morphological together with decrease in the AaAQP4 and AaV-H+-ATPase primary transcript levels suggest that squamocin may affect osmoregulation and ion-regulation of this insect followed by death.
Published Version
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