Modern Perspectives of Curcumin and its Derivatives as Promising Bioactive and Pharmaceutical Agents

Abstract

In the current era of eco-preservation, global research has focused on using raw and sustainable natural products with new clean technologies. New pharmaceutical or pharmaceutical agents from renewable sources are considered as essential as pure chemicals or certified fragments. A variety of natural phytoconstituents have been shown to reduce the risk of certain diseases and disorders, for example, diabetes, heart disease, cancer, neoplastic, and other health disorders. And, therefore, ongoing efforts to identify specific chemicals in these foods may contribute to their positive effects on beans/grains, fruits, vegetables, etc. Many of the phytochemicals that occurred as natural products in medicinal plants offer many opportunities in natural product research due to their versatile uses and various formulation. Curcuminoids are polyphenols found in the under-soil rhizome of Curcuma longa L. and have been used for centuries for spice, culinary, and food coloring purposes, and description also documented in the alternative system of medicines such as Indian Ayurveda, Sidha, Unani, and Chinese medicine system. It has been observed from the literature that the C. longa rhizome or commonly known as turmeric has several phytochemicals to possess anti-inflammatory, hepatoprotective, neuroprotective, antioxidant, anticancer, cardioprotective properties, and many more. The review highlights the recent progress of curcumin and its derivatives as promising bioactive and pharmaceutical agents with emphasis on future research dimensions required to propose curcuminoids as promising candidates for therapeutic and pharmacology-related sectors.