Abstract
The aim – to study the effectiveness of zinc salts in the treatment of patients with neurological forms of Wilson's disease (WD). Materials and methods. The analysis of the treatment results of 128 patients with hepatocerebral degeneration (71 men and 57 women) in the State Institution “Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine” was carried out. At the time of hospitalization, the age of patients ranged from 5 to 55 years, an average of 27.3 years, and at the time of debut of the disease - from 1 year to 40 years, an average of 21.3 years. 33 patients underwent monotherapy with zinc salts, 63 – combined therapy with small doses of penicillamine and zinc salts, 32 – monotherapy with penicillamine. Results. Because of the treatment, 67.1 % of patients showed an improvement in neuropsychiatric status: speech improved significantly, tremor of the extremities and the amplitude of hyperkinesis decreased, muscle tone decreased, and cognitive functions improved. According to the international two-level rating scale (UWDRS), the total pathology index decreased by 21 points. Zinc salts are effective and low-toxic and can be the drug of choice in the treatment of patients with hepatocerebral degeneration in the pre-symptomatic stage of the disease, as well as at the stage of maintenance treatment, both as monotherapy and in combination with penicillamine. However, zinc salts and penicillamine are not enough for the treatment and rehabilitation of patients with hepatocerebral degeneration. Therefore, taking into account the clinical picture and the data of additional research methods, it is necessary to conduct courses of symptomatic treatment at least 1-2 times a year. Conclusions. Thus, it can be noted that zinc salts are very effective and low toxic, and, therefore, can be the drug of choice in the treatment of patients with HCD in the pre-symptomatic stage of the disease, as well as at the stage of maintenance therapy as a single drug, and in combination with penicillamine or other chelate drugs.
Highlights
Hepatocerebral degeneration (HCD), or Wilson’s disease (WD), is a severe chronic progressive dis-MODERN ASPECTS OF PATHOGENETIC TREATMENT WITH ZINC SALTS OF PATIENTSWITH WILSON'S DISEASE IN UKRAINE predominantly patients who were treated with D-penicillamine
Our clinical case can serve as an illustration of the effectiveness of monotherapy for patients with HCD zinc salts
Penicillamine was cancelled and monotherapy was prescribed with zinc salts of 1 tablet
Summary
Hepatocerebral degeneration (HCD), or Wilson’s disease (WD), is a severe chronic progressive dis-MODERN ASPECTS OF PATHOGENETIC TREATMENT WITH ZINC SALTS OF PATIENTSWITH WILSON'S DISEASE IN UKRAINE predominantly patients who were treated with D-penicillamine. Hepatocerebral degeneration (HCD), or Wilson’s disease (WD), is a severe chronic progressive dis-. MODERN ASPECTS OF PATHOGENETIC TREATMENT WITH ZINC SALTS OF PATIENTS. WITH WILSON'S DISEASE IN UKRAINE predominantly patients who were treated with D-penicillamine. In this group, severe side effects were reported in more than 30 % of ease with a genetically impaired. In this regard, accordmetabolic disorder of copper. The ATP7B gene, located on the Department of Autoimmune and degenerative diseases of mine should not be a drug that long arm of the 13th chromonervous system is preferred over zinc salts in the some and encoding the P-type. Due to the is responsible for the developof the National Academy of Medical Sciences of Ukraine fact that the chelate drug peniment of HCD. Pavlova str., Kharkiv, Ukraine, 61068 cillamine often causes complicathe copper molecule is integrated
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Technology transfer: innovative solutions in medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
