Abstract

Aquametric and thermodynamic characteristics of the new excipients lactose 80 m, agglomerated lactose (tablettose 80), and microcellulose 101 – 200 were studied. Microcellulose 101 – 200 was more hygroscopic than both lactose derivatives at all values of relative humidity. Lactose 80 m and tablettose 80 had different thermodynamic characteristics that were probably explained by differences in the technology of raw material production. Comparative analysis of trace elements in the studied excipients by atomic absorption spectroscopy (AAS) and x-ray fluorescence (XRF) methods was carried out. Both methods gave comparable results but XRF gave high reproducibility and did not require long sample preparation. The toxicological safety of the analyzed compounds was established.

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