Abstract
The type and number of control formulations to be used in model studies to evaluate new fluoride systems require careful consideration. While many controls may be justified on the grounds of scientific interest, some models can handle only small numbers of treatments without the statistical power of studies being compromised. In those cases, the results of more than one study may need to be combined. Current models for evaluating fluoride products have most often been developed with systems containing ionic fluoride in mind. To test new types of delivery vehicles or formulations which contain new fluoride agents, model protocols may need to be revised in order to account properly for differences in modes of action-for example, in rates of reaction with enamel or site specificity of active ingredient delivery in the mouth.
Published Version
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