Abstract
A model of the control of the respiratory cycle pattern is presented in which the airflow shape is determined by a dynamic optimization problem. The inspiratory and expiratory phases have different performance criteria both of which are related to the oxygen cost of breathing, and to the minimization of tissue damage and control difficulties. The model successfully predicts various patterns of spontaneous breathing during both inspiration and expiration. The effects of applying elastic and resistive loads to the respiratory system can also be predicted. The model performance is in good agreement with the experimental observation that increasing resistance makes the airflow patterns more rectangular.
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