Abstract
Peel tests were performed on pharmaceutical drug patches which consisted of a polyester backing membrane supporting an acrylic pressure-sensitive adhesive (PSA) (without and with an anti-fungal drug present) adhered to a polyethylene substrate. Interfacial separation of the PSA from the polyethylene substrate was observed in most cases. Finite element (FE) peeling simulations were conducted which characterized the backing-membrane as an elasto-plastic power-law material, the PSA as a viscoelastic material and the interfacial properties with a cohesive zone model (CZM). The mechanical response of the backing membrane and the PSA were measured from tensile experiments while the rate-dependent cohesive zone parameters, i.e. the fracture energy and maximum stress, were measured directly from poker-chip probe tack tests. The numerical results from the CZM/FE simulations and the experimental values of the peel forces as a function of the peel angle, peel speed and PSA thickness were found to be in good agreement. Two different anti-fungal drugs were added to the PSA and the influence of the drug was investigated using contact angle measurements, tensile tests, dynamic mechanical analysis and peel tests.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.