Abstract
A surface plasmon resonance (SPR) biosensor based on a graphene nanoribbon array in a microfluidic flow cell operating in a flow-over format is studied. The optical response of the biosensor is numerically obtained by using rigorous couple wave analysis (RCWA). The performance of the biosensor is described in terms of the limit of detection, which is calculated as a function of key nanoribbon dimensional parameters, such as strip thickness and width, and fill fraction (nanoribbon width to array period ratio). The analysis shows that there are specific values of the fill fraction that optimize, that is, minimize, the limit of detection for particular nanoribbon dimensions. Fabrication issues are also discussed. This study is expected to assist in the design and implementation of SPR biosensors based on nanopatterned 2D materials.
Highlights
Surface plasmon resonance (SPR) biosensors make use of surface plasmon polariton (SPP) waves to probe interactions between biomolecules and the sensor sensitive surface
Assuming that the optical response of the biosensor is recorded by using a scientific grade CCD detector, with Nt = 100 frames averaged for each time record and Ns = 400 pixels included in the data processing, the noise (σ) can be estimated by means of the following expression [16]: where k1 is the association rate constant, Γ0 is the surface density of the biolayer, T is the total detection time, and km is the diffusion-limited mass transport coefficient, which is given by [15]: km =
The performance of a graphene nanoribbon array–based SPR biosensor operating in a microfluidic flow cell has been analyzed through numerical modeling
Summary
Surface plasmon resonance (SPR) biosensors make use of surface plasmon polariton (SPP) waves to probe interactions between biomolecules and the sensor sensitive surface. SPR-based RI optical sensors using nanoribbons (thin strips with width less than 100 nm) of graphene and WSe2 have been proposed and theoretically analyzed [13].
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