Abstract
Previous models of the oxygen-hemoglobin saturation curve are discussed for oxygen transfer in laminar blood flow. A second-order approximation is introduced and evaluated for modeling the saturation curve. Prior experimental results have shown that at high shear rates the effective diffusion coefficient of oxygen is a strong function of the slope of the hemoglobin saturation curve. The impact of this shear-induced augmentation on transfer at large oxygen driving pressures is discussed. An augmentation model is presented to evaluate this effect using multiple diffusion coefficient solutions for a tubular geometry. The results compare well with previous experimental measurements.
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